Interactions médicamenteuses
Methylene blue + Nortriptyline
Gravité: Contre-indiquée
Methylene blue and Nortriptyline: contraindicated interaction.
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Résumé
Methylene blue inhibits MAO-A, and combining it with serotonergic drugs such as nortriptyline can cause serotonin syndrome, which may be severe. The FDA has issued a warning on this interaction.
Ce que signifie cette interaction, en termes simples
Methylene blue and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
MAO-A inhibition by methylene blue added to serotonin reuptake inhibition by nortriptyline.
Conduite à tenir
Avoid the combination in non-emergency settings. If methylene blue is urgent, stop the serotonergic drug and monitor for CNS toxicity for up to two weeks or 24 hours after the last methylene blue dose, whichever comes first.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Nortriptyline
- Disopyramide + Nortriptyline Contre-indiquée
- Dofetilide + Nortriptyline Contre-indiquée
- Dronedarone + Nortriptyline Contre-indiquée
- Ibutilide + Nortriptyline Contre-indiquée
- Isocarboxazid + Nortriptyline Contre-indiquée
- Nortriptyline + Pentamidine Contre-indiquée
Questions fréquentes
Can I take Methylene blue with Nortriptyline?
MediHelp rates the interaction as contraindicated. Methylene blue and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A, and combining it with serotonergic drugs such as nortriptyline can cause serotonin syndrome, which may be severe. The FDA has issued a warning on this interaction.
How serious is the interaction between Methylene blue and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in non-emergency settings. If methylene blue is urgent, stop the serotonergic drug and monitor for CNS toxicity for up to two weeks or 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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