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Interactions médicamenteuses

Dofetilide + Nortriptyline

Gravité: Contre-indiquée

Dofetilide and Nortriptyline: contraindicated interaction.

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Résumé

Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.

Ce que signifie cette interaction, en termes simples

Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dofetilide belongs to Cardiovascular; Nortriptyline belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive prolongation of cardiac repolarization via potassium channel effects.

Conduite à tenir

Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dofetilide with Nortriptyline?

MediHelp rates the interaction as contraindicated. Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.

How serious is the interaction between Dofetilide and Nortriptyline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.

What other medicines interact with Nortriptyline?

MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dronedarone, Ibutilide. The full list is on the Nortriptyline page.

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