Interactions médicamenteuses
Isocarboxazid + Nortriptyline
Gravité: Contre-indiquée
Isocarboxazid and Nortriptyline: contraindicated interaction.
Dernière mise à jour
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Résumé
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
Ce que signifie cette interaction, en termes simples
Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Pourquoi elle survient
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
Conduite à tenir
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Nortriptyline
- Disopyramide + Nortriptyline Contre-indiquée
- Dofetilide + Nortriptyline Contre-indiquée
- Dronedarone + Nortriptyline Contre-indiquée
- Ibutilide + Nortriptyline Contre-indiquée
- Methylene blue + Nortriptyline Contre-indiquée
- Nortriptyline + Pentamidine Contre-indiquée
Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amoxapine + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
Questions fréquentes
Can I take Isocarboxazid with Nortriptyline?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Isocarboxazid and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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