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Interactions médicamenteuses

Miconazole + Pimozide

Gravité: Majeure

Miconazole and Pimozide: major interaction.

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Résumé

Vaginal or topical miconazole has low systemic absorption, but systemic exposure can occur and miconazole is a potent CYP3A4 inhibitor. Pimozide has a narrow therapeutic index and QT prolongation risk. Interaction is mainly relevant for oral or buccal miconazole.

Ce que signifie cette interaction, en termes simples

Miconazole and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Miconazole belongs to Anti Fungals; Pimozide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Miconazole inhibits CYP3A4 metabolism of pimozide, raising levels and QT prolongation risk.

Conduite à tenir

Avoid systemic (oral gel, buccal) miconazole with pimozide. With vaginal use, prefer an alternative antifungal if the patient has QT risk factors.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Miconazole with Pimozide?

MediHelp rates the interaction as major. Miconazole and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vaginal or topical miconazole has low systemic absorption, but systemic exposure can occur and miconazole is a potent CYP3A4 inhibitor. Pimozide has a narrow therapeutic index and QT prolongation risk. Interaction is mainly relevant for oral or buccal miconazole.

How serious is the interaction between Miconazole and Pimozide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic (oral gel, buccal) miconazole with pimozide. With vaginal use, prefer an alternative antifungal if the patient has QT risk factors.

What other medicines interact with Miconazole?

MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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