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Interactions médicamenteuses

Morphine + Phenelzine

Gravité: Contre-indiquée

Morphine and Phenelzine: contraindicated interaction.

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Résumé

Opioids given with non-selective MAO inhibitors such as phenelzine can lead to serotonin syndrome or to severe CNS depression, hypotension and hyperpyrexia. The reaction is best documented with meperidine, but labeling for morphine advises against use with MAOIs.

Ce que signifie cette interaction, en termes simples

Morphine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Morphine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid through mechanisms not fully established for morphine.

Conduite à tenir

Avoid morphine during MAOI therapy and for 14 days after stopping phenelzine; choose a non-opioid or alternative analgesic. If an opioid is unavoidable, use specialist supervision with close monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Morphine with Phenelzine?

MediHelp rates the interaction as contraindicated. Morphine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with non-selective MAO inhibitors such as phenelzine can lead to serotonin syndrome or to severe CNS depression, hypotension and hyperpyrexia. The reaction is best documented with meperidine, but labeling for morphine advises against use with MAOIs.

How serious is the interaction between Morphine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during MAOI therapy and for 14 days after stopping phenelzine; choose a non-opioid or alternative analgesic. If an opioid is unavoidable, use specialist supervision with close monitoring.

What other medicines interact with Morphine?

MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.

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