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Interactions médicamenteuses

Isocarboxazid + Morphine

Gravité: Contre-indiquée

Isocarboxazid and Morphine: contraindicated interaction.

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Résumé

Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.

Ce que signifie cette interaction, en termes simples

Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Morphine belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Nonselective MAO inhibition combined with opioid effects leads to serotonergic toxicity and unpredictable CNS and cardiovascular responses.

Conduite à tenir

Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isocarboxazid with Morphine?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.

How serious is the interaction between Isocarboxazid and Morphine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.

What other medicines interact with Morphine?

MediHelp also lists interactions of Morphine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Morphine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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