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Interactions médicamenteuses

Morphine + Tranylcypromine

Gravité: Contre-indiquée

Morphine and Tranylcypromine: contraindicated interaction.

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Résumé

Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.

Ce que signifie cette interaction, en termes simples

Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Morphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Irreversible MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid.

Conduite à tenir

Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Morphine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.

How serious is the interaction between Morphine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.

What other medicines interact with Morphine?

MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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