Interactions médicamenteuses
Olanzapine / samidorphan + Oxymorphone
Gravité: Contre-indiquée
Olanzapine / samidorphan and Oxymorphone: contraindicated interaction.
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Résumé
Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
Ce que signifie cette interaction, en termes simples
Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Pharmacodynamic antagonism at opioid receptors by samidorphan.
Conduite à tenir
Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Oxymorphone
- Alvimopan + Oxymorphone Contre-indiquée
- Ethanol + Oxymorphone Contre-indiquée
- Isocarboxazid + Oxymorphone Contre-indiquée
- Oxymorphone + Phenelzine Contre-indiquée
- Oxymorphone + Selegiline transdermal Contre-indiquée
- Oxymorphone + Sodium oxybate Contre-indiquée
Questions fréquentes
Can I take Olanzapine / samidorphan with Oxymorphone?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks oxymorphone's effect and can precipitate acute withdrawal in opioid-dependent patients. Analgesia may fail.
How serious is the interaction between Olanzapine / samidorphan and Oxymorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; allow at least 7 days opioid-free for short-acting and 14 days for long-acting opioids before starting. Use another antipsychotic if opioids are needed.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
