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Interactions médicamenteuses

Oxymorphone + Sodium oxybate

Gravité: Contre-indiquée

Oxymorphone and Sodium oxybate: contraindicated interaction.

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Résumé

Both drugs depress the central nervous system, and combining them can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling restricts its use with other CNS depressants such as opioids.

Ce que signifie cette interaction, en termes simples

Oxymorphone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Oxymorphone belongs to Musculoskeletal; Sodium oxybate belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic CNS and respiratory depression via opioid receptor and GABA-B/GHB receptor activity.

Conduite à tenir

Avoid the combination; choose a non-opioid analgesic or alternative oxybate-free therapy where possible. If it cannot be avoided, use the lowest doses for the shortest time and monitor respiratory status and sedation closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Oxymorphone with Sodium oxybate?

MediHelp rates the interaction as contraindicated. Oxymorphone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs depress the central nervous system, and combining them can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling restricts its use with other CNS depressants such as opioids.

How serious is the interaction between Oxymorphone and Sodium oxybate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-opioid analgesic or alternative oxybate-free therapy where possible. If it cannot be avoided, use the lowest doses for the shortest time and monitor respiratory status and sedation closely.

What other medicines interact with Oxymorphone?

MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.

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