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Interactions médicamenteuses

Isocarboxazid + Oxymorphone

Gravité: Contre-indiquée

Isocarboxazid and Oxymorphone: contraindicated interaction.

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Résumé

Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.

Ce que signifie cette interaction, en termes simples

Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition potentiates opioid CNS effects and may cause serotonergic or autonomic toxicity; the exact mechanism varies by opioid.

Conduite à tenir

Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isocarboxazid with Oxymorphone?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Oxymorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia and agitation. Labeling advises against use during or within 14 days of MAOI therapy.

How serious is the interaction between Isocarboxazid and Oxymorphone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use oxymorphone during or within 14 days after stopping isocarboxazid. Choose a non-opioid or alternative analgesic strategy.

What other medicines interact with Oxymorphone?

MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Olanzapine / samidorphan. The full list is on the Oxymorphone page.

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