Interactions médicamenteuses
Oritavancin + Warfarin
Gravité: Modérée
Oritavancin and Warfarin: moderate interaction.
Dernière mise à jour
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Résumé
Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.
Ce que signifie cette interaction, en termes simples
Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oritavancin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Pourquoi elle survient
Oritavancin binds and interferes with phospholipid reagents used in clotting assays, and may weakly inhibit CYP2C9 and so reduce warfarin clearance.
Conduite à tenir
Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Oritavancin
- Heparin + Oritavancin Contre-indiquée
- Carbamazepine + Oritavancin Mineure
- Cyclosporin + Oritavancin Mineure
- Ethosuximide + Oritavancin Mineure
- Flecainide + Oritavancin Mineure
- Oritavancin + Phenytoin Mineure
Autres interactions de Warfarin
- Defibrotide + Warfarin Contre-indiquée
- Ketorolac + Warfarin Contre-indiquée
- Abciximab + Warfarin Majeure
- Acetylsalicylic acid + Warfarin Majeure
- Adagrasib + Warfarin Majeure
- Amiodarone + Warfarin Majeure
Questions fréquentes
Can I take Oritavancin with Warfarin?
MediHelp rates the interaction as moderate. Oritavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oritavancin artificially prolongs PT/INR and aPTT in laboratory tests for hours to days after dosing, so coagulation results may not reflect true anticoagulation in warfarin-treated patients. Oritavancin may also modestly raise warfarin exposure, so true bleeding risk may be increased.
How serious is the interaction between Oritavancin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on INR measurements shortly after oritavancin dosing and monitor the patient clinically for bleeding. Consider alternative anticoagulation monitoring or a different antibiotic if tight INR control is needed.
What other medicines interact with Oritavancin?
MediHelp also lists interactions of Oritavancin with, for example, Heparin, Carbamazepine, Cyclosporin. The full list is on the Oritavancin page.
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