दवाओं की अंतःक्रिया
Alvimopan + Diphenoxylate-atropine
गंभीरता: गंभीर
Alvimopan and Diphenoxylate-atropine: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Alvimopan is a peripherally acting mu-opioid antagonist, and diphenoxylate is an opioid. Opioid-exposed patients may be more sensitive to alvimopan and can develop abdominal pain, nausea, vomiting and diarrhea, while antidiarrheal efficacy may be reduced.
इस इंटरैक्शन का सरल भाषा में अर्थ
Alvimopan and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Competitive antagonism of peripheral mu-opioid receptors by alvimopan opposes diphenoxylate's gut effects.
क्या करें
Avoid alvimopan in patients who have been taking opioids, including diphenoxylate, for a prolonged period before surgery. Use alternative management for diarrhea and postoperative ileus if appropriate.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Alvimopan और Diphenoxylate-atropine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Diphenoxylate-atropine के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Alvimopan with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Alvimopan and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Alvimopan is a peripherally acting mu-opioid antagonist, and diphenoxylate is an opioid. Opioid-exposed patients may be more sensitive to alvimopan and can develop abdominal pain, nausea, vomiting and diarrhea, while antidiarrheal efficacy may be reduced.
How serious is the interaction between Alvimopan and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid alvimopan in patients who have been taking opioids, including diphenoxylate, for a prolonged period before surgery. Use alternative management for diarrhea and postoperative ileus if appropriate.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
