दवाओं की अंतःक्रिया
Bupropion-naltrexone + Hydrocodone
गंभीरता: निषिद्ध
Bupropion-naltrexone and Hydrocodone: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
इस इंटरैक्शन का सरल भाषा में अर्थ
Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.
ऐसा क्यों होता है
Naltrexone competitively antagonizes opioid receptors; bupropion inhibits CYP2D6 and lowers seizure threshold.
क्या करें
Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Bupropion-naltrexone और Hydrocodone की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Bupropion-naltrexone के अन्य इंटरैक्शन
Hydrocodone के अन्य इंटरैक्शन
- Alvimopan + Hydrocodone निषिद्ध
- Hydrocodone + Isocarboxazid निषिद्ध
- Hydrocodone + Olanzapine / samidorphan निषिद्ध
- Hydrocodone + Phenelzine निषिद्ध
- Alfentanil + Hydrocodone गंभीर
- Alprazolam + Hydrocodone गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Bupropion-naltrexone with Hydrocodone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
How serious is the interaction between Bupropion-naltrexone and Hydrocodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydromorphone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
