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दवाओं की अंतःक्रिया

Duloxetine + Pefloxacin

गंभीरता: गंभीर

Duloxetine and Pefloxacin: major interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.

इस इंटरैक्शन का सरल भाषा में अर्थ

Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Duloxetine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.

साक्ष्य स्तर: Moderate

ऐसा क्यों होता है

Inhibition of CYP1A2-mediated duloxetine metabolism by pefloxacin.

क्या करें

Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.

फार्मासिस्ट से क्या पूछें

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Duloxetine और Pefloxacin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Duloxetine with Pefloxacin?

MediHelp rates the interaction as major. Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.

How serious is the interaction between Duloxetine and Pefloxacin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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