दवाओं की अंतःक्रिया
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol
गंभीरता: निषिद्ध
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cobicistat is a strong CYP3A4 inhibitor that increases salmeterol exposure, with risk of QT prolongation and arrhythmia. It also raises systemic fluticasone levels, so Cushing's syndrome and adrenal suppression can occur with prolonged use.
इस इंटरैक्शन का सरल भाषा में अर्थ
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Strong CYP3A4 inhibition by cobicistat reduces clearance of salmeterol and fluticasone.
क्या करें
Avoid the combination and consider an alternative such as beclomethasone with a non-CYP3A4-dependent LABA. If it cannot be avoided, monitor ECG, potassium and adrenal function.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Elvitegravir / cobicistat / emtricitabine / tenofovir df और Fluticasone-salmeterol की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Fluticasone-salmeterol के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fluticasone-salmeterol?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor that increases salmeterol exposure, with risk of QT prolongation and arrhythmia. It also raises systemic fluticasone levels, so Cushing's syndrome and adrenal suppression can occur with prolonged use.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative such as beclomethasone with a non-CYP3A4-dependent LABA. If it cannot be avoided, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Fosamprenavir, Indinavir. The full list is on the Fluticasone-salmeterol page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
