दवाओं की अंतःक्रिया
Fluticasone-salmeterol + Fosamprenavir
गंभीरता: निषिद्ध
Fluticasone-salmeterol and Fosamprenavir: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Fosamprenavir (as amprenavir, usually ritonavir-boosted) inhibits CYP3A4 and can substantially increase salmeterol exposure. This raises the risk of QT prolongation, tachycardia and arrhythmia. Systemic fluticasone exposure also rises, risking adrenal suppression.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fluticasone-salmeterol and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
CYP3A4 inhibition reduces the metabolism of salmeterol and fluticasone.
क्या करें
Avoid concurrent use and switch to an alternative inhaled corticosteroid/LABA less reliant on CYP3A4, such as beclomethasone-based therapy. Monitor ECG and cortisol-related effects if it cannot be avoided.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fluticasone-salmeterol और Fosamprenavir की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Fluticasone-salmeterol के अन्य इंटरैक्शन
- Darunavir + Fluticasone-salmeterol निषिद्ध
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol निषिद्ध
- Fluticasone-salmeterol + Indinavir निषिद्ध
- Fluticasone-salmeterol + Lopinavir निषिद्ध
- Fluticasone-salmeterol + Nelfinavir निषिद्ध
- Fluticasone-salmeterol + Ritonavir निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Fluticasone-salmeterol with Fosamprenavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir (as amprenavir, usually ritonavir-boosted) inhibits CYP3A4 and can substantially increase salmeterol exposure. This raises the risk of QT prolongation, tachycardia and arrhythmia. Systemic fluticasone exposure also rises, risking adrenal suppression.
How serious is the interaction between Fluticasone-salmeterol and Fosamprenavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and switch to an alternative inhaled corticosteroid/LABA less reliant on CYP3A4, such as beclomethasone-based therapy. Monitor ECG and cortisol-related effects if it cannot be avoided.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Indinavir. The full list is on the Fluticasone-salmeterol page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
