दवाओं की अंतःक्रिया
Fluticasone-salmeterol + Lopinavir
गंभीरता: निषिद्ध
Fluticasone-salmeterol and Lopinavir: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Lopinavir/ritonavir strongly inhibits CYP3A4 and can greatly increase salmeterol exposure, with risk of QT prolongation and arrhythmias. Systemic fluticasone exposure also rises, which can lead to Cushing's syndrome and adrenal suppression.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fluticasone-salmeterol and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluticasone-salmeterol belongs to Respiratory; Lopinavir belongs to Anti Virals.
ऐसा क्यों होता है
Strong CYP3A4 inhibition reduces clearance of salmeterol and fluticasone.
क्या करें
Avoid the combination and switch to an alternative such as beclomethasone with a different LABA. If unavoidable, monitor ECG, potassium and adrenal function.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fluticasone-salmeterol और Lopinavir की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Fluticasone-salmeterol के अन्य इंटरैक्शन
- Darunavir + Fluticasone-salmeterol निषिद्ध
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol निषिद्ध
- Fluticasone-salmeterol + Fosamprenavir निषिद्ध
- Fluticasone-salmeterol + Indinavir निषिद्ध
- Fluticasone-salmeterol + Nelfinavir निषिद्ध
- Fluticasone-salmeterol + Ritonavir निषिद्ध
Lopinavir के अन्य इंटरैक्शन
- Alfuzosin + Lopinavir निषिद्ध
- Avanafil + Lopinavir निषिद्ध
- Cisapride + Lopinavir निषिद्ध
- Dronedarone + Lopinavir निषिद्ध
- Eletriptan + Lopinavir निषिद्ध
- Eplerenone + Lopinavir निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Fluticasone-salmeterol with Lopinavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir/ritonavir strongly inhibits CYP3A4 and can greatly increase salmeterol exposure, with risk of QT prolongation and arrhythmias. Systemic fluticasone exposure also rises, which can lead to Cushing's syndrome and adrenal suppression.
How serious is the interaction between Fluticasone-salmeterol and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to an alternative such as beclomethasone with a different LABA. If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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