दवाओं की अंतःक्रिया
Fluticasone-salmeterol + Ritonavir
गंभीरता: निषिद्ध
Fluticasone-salmeterol and Ritonavir: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluticasone-salmeterol belongs to Respiratory; Ritonavir belongs to Anti Virals.
ऐसा क्यों होता है
Potent CYP3A4 inhibition by ritonavir reduces clearance of salmeterol and fluticasone.
क्या करें
Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fluticasone-salmeterol और Ritonavir की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Fluticasone-salmeterol के अन्य इंटरैक्शन
- Darunavir + Fluticasone-salmeterol निषिद्ध
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol निषिद्ध
- Fluticasone-salmeterol + Fosamprenavir निषिद्ध
- Fluticasone-salmeterol + Indinavir निषिद्ध
- Fluticasone-salmeterol + Lopinavir निषिद्ध
- Fluticasone-salmeterol + Nelfinavir निषिद्ध
Ritonavir के अन्य इंटरैक्शन
- Alfuzosin + Ritonavir निषिद्ध
- Amiodarone + Ritonavir निषिद्ध
- Avanafil + Ritonavir निषिद्ध
- Colchicine + Ritonavir निषिद्ध
- Dronedarone + Ritonavir निषिद्ध
- Eletriptan + Ritonavir निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Fluticasone-salmeterol with Ritonavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.
How serious is the interaction between Fluticasone-salmeterol and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
