दवाओं की अंतःक्रिया
Glycerol phenylbutyrate + Valproic acid
गंभीरता: गंभीर
Glycerol phenylbutyrate and Valproic acid: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, whereas valproate can cause hyperammonemia, sometimes severe, by interfering with the urea cycle. Valproate can therefore counteract the treatment and may precipitate hyperammonemic crises in these patients.
इस इंटरैक्शन का सरल भाषा में अर्थ
Glycerol phenylbutyrate and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glycerol phenylbutyrate belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
ऐसा क्यों होता है
Valproate inhibits urea cycle function (carbamoyl phosphate synthetase I via carnitine depletion and metabolite effects), opposing ammonia-lowering therapy.
क्या करें
Avoid valproate in urea cycle disorders when possible and choose another anticonvulsant. If it must be used, monitor plasma ammonia closely and adjust the nitrogen-scavenger therapy.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Glycerol phenylbutyrate और Valproic acid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Valproic acid के अन्य इंटरैक्शन
Glycerol phenylbutyrate के अन्य इंटरैक्शन
- Dexamethasone + Glycerol phenylbutyrate गंभीर
- Glycerol phenylbutyrate + Sodium valproate गंभीर
- Cyclosporin + Glycerol phenylbutyrate मध्यम
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate मध्यम
- Dexamethasone-tobramycin + Glycerol phenylbutyrate मध्यम
- Fludrocortisone + Glycerol phenylbutyrate मध्यम
अक्सर पूछे जाने वाले प्रश्न
Can I take Glycerol phenylbutyrate with Valproic acid?
MediHelp rates the interaction as major. Glycerol phenylbutyrate and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, whereas valproate can cause hyperammonemia, sometimes severe, by interfering with the urea cycle. Valproate can therefore counteract the treatment and may precipitate hyperammonemic crises in these patients.
How serious is the interaction between Glycerol phenylbutyrate and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid valproate in urea cycle disorders when possible and choose another anticonvulsant. If it must be used, monitor plasma ammonia closely and adjust the nitrogen-scavenger therapy.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
