Riferimento farmaci
Eltrombopag
Eltrombopag is a medicine in the class miscellaneous. It is used for aplastic anemia.
- Classe del farmaco: Miscellaneous
- Indicato per: aplastic anemia
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- B02BX05
- Forme farmaceutiche comuni
- compressa, sospensione orale
- Dosaggi comuni
- 50 mg, 25 mg
- Interazioni note
- 124 (Moderata: 66 · Minore: 58)
- Nomi commerciali
- 14
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Small-molecule thrombopoietin (TPO)-receptor agonist that interacts with human TPO receptor transmembrane domain of human TPO-receptor & initiates signaling cascades that induce proliferation & differentiation of megakaryocytes from bone marrow progenitor cells
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Chronic Immune Thrombocytopenia (ITP): Initial: 50 mg PO qDay, Adjust dose to achieve and maintain platelet count (Plt) >50 x 10^9/L to reduce risk of bleeding; not to exceed 75 mg/day.
Gravidanza e allattamento
- Gravidanza
- Unknown Case reports are too few to assess risk; in rats, maternally toxic doses caused embryo death and lower fetal weight. EU label: not recommended in pregnancy or in women not using contraception. Use effective contraception during and for 7 days after treatment.
- Allattamento
- Unsafe No human milk data; it reached rat pups through milk. US label: breastfeeding not recommended. It clears about 8 days after the last dose. LactMed: one infant had prolonged high platelets; if used, monitor the infant's blood counts.
Effetti indesiderati segnalati
- Headache
- Fatigue
- Upper respiratory tract infection
- Nasopharyngitis
- Nausea
- Anemia
Chi deve prestare attenzione
- May develop or worsen cataracts; screen before administering and during treatment
- Thrombotic/thromboembolic complications reported; have included both venous and arterial events and were observed at low and at normal platelet counts.
- Portal vein thrombosis reported in patients with chronic liver disease receiving therapy
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (124)
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
- Berotralstat + Eltrombopag Moderate
- Butabarbital + Eltrombopag Moderate
- Butalbital + Eltrombopag Moderate
- Calcium + Eltrombopag Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Domande frequenti
What is Eltrombopag used for?
Eltrombopag is a medicine in the class miscellaneous. It is used for Aplastic anemia, Thrombocytopenia.
What side effects have been reported with Eltrombopag?
Headache, Fatigue, Upper respiratory tract infection, Nasopharyngitis, Nausea, Anemia.
Can Eltrombopag be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Case reports are too few to assess risk; in rats, maternally toxic doses caused embryo death and lower fetal weight. EU label: not recommended in pregnancy or in women not using contraception. Use effective contraception during and for 7 days after treatment. Breastfeeding: Unsafe. No human milk data; it reached rat pups through milk. US label: breastfeeding not recommended. It clears about 8 days after the last dose. LactMed: one infant had prolonged high platelets; if used, monitor the infant's blood counts.
What does Eltrombopag interact with?
MediHelp lists 124 known interactions for Eltrombopag. Moderate: 66 · Minor: 58. The most serious include Alpelisib, Aluminum hydroxide, Amobarbital.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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