Riferimento farmaci
Galcanezumab
Galcanezumab is a medicine in the class central nervous system. It is used for cluster headache.
- Classe del farmaco: Central Nervous System
- Indicato per: cluster headache
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Central Nervous System
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 120 mg/ml, 100 mg/ml
- Interazioni note
- 3 (Moderata: 3)
- Nomi commerciali
- 5
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Humanized monoclonal antibody; binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Migraine Prophylaxis: Loading dose: 240 mg SC once (ie, 2 consecutive 120-mg SC injections), Maintenance dose: 120 mg SC monthly
Gravidanza e allattamento
- Gravidanza
- Unknown No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy.
- Allattamento
- Unknown No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
Effetti indesiderati segnalati
- Injection site reactions
- Angioedema
Controindicazioni
- Serious hypersensitivity to galcanezumab-gnlm or to any of the excipients.
Chi deve prestare attenzione
- Hypersensitivity reactions (dyspnea, urticaria, rash; anaphylaxis and angioedema postmarketing) can occur, even days after administration, and may be prolonged. If a serious reaction occurs, discontinue and treat appropriately.
- Constipation with serious complications, including hospitalization and surgery, has been reported, usually after the first dose. Monitor for severe constipation; medications that reduce GI motility may increase the risk.
- New-onset or worsening hypertension has been reported, most often within 7 days of starting. Monitor blood pressure and consider discontinuation if no other cause is found or BP is inadequately controlled.
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Interazioni principali (3)
- Efgartigimod / hyaluronidase sc + Galcanezumab Moderate
- Efgartigimod alfa + Galcanezumab Moderate
- Galcanezumab + Rozanolixizumab Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Galcanezumab used for?
Galcanezumab is a medicine in the class central nervous system. It is used for Cluster headache, Migraine.
What side effects have been reported with Galcanezumab?
Injection site reactions, Angioedema.
Can Galcanezumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy. Breastfeeding: Unknown. No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
What does Galcanezumab interact with?
MediHelp lists 3 known interactions for Galcanezumab. Moderate: 3. The most serious include Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rozanolixizumab.
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