Riferimento farmaci
Ixekizumab
Ixekizumab is a medicine in the class miscellaneous. It is used for ankylosing spondylitis.
- Classe del farmaco: Miscellaneous
- Indicato per: ankylosing spondylitis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- L04AC13
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 80 mg/ml
- Interazioni note
- 13 (Maggiore: 2 · Moderata: 2 · Minore: 9)
- Nomi commerciali
- 5
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Humanized monoclonal IgG4 antibody that targets interleukin-17A (IL-17A) and neutralizes the proinflammatory effects of IL-17A
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Psoriasis (Week 0): 160 mg SC (two 80-mg injections), THEN Weeks 2, 4, 6, 8, 10, and 12: 80 mg SC q2Weeks, THEN Week 16 and thereafter: 80 mg SC q4Weeks
Gravidanza e allattamento
- Gravidanza
- Unknown Human IgG is known to cross the placental barrier; therefore, the drug may be transmitted from the mother to the developing fetus
- Allattamento
- Unknown There are no available data on presence of this drug in human milk, effects on breastfed infant, or on milk production; the drug was detected in the milk of lactating cynomolgus monkeys; when a drug is present in animal milk, it is likely that the drug will be present in human milk
Effetti indesiderati segnalati
- Tinea infections
- Serious infections
- Upper respiratory tract infections
- Injection site reacation
- Thrombocytopenia
- Nausea
Controindicazioni
- Hypersensitivity reaction (eg, anaphylaxis) to drug or excipients
Chi deve prestare attenzione
- Patients receiving treatment may be at increased risk of inflammatory bowel disease; in clinical trials, Crohn’s disease and ulcerative colitis, including exacerbations, occurred at a greater frequency in treated group than placebo control group; during treatment, monitor for onset or exacerbation of inflammatory bowel disease and if IBD occurs...
- ... discontinue therapy and initiate appropriate medical management
- Prior to initiating drug, consider completion of all age-appropriate immunizations; avoid use of live vaccines; no data are available on the response to live vaccines while taking ixekizumab
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (13)
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
- Ethosuximide + Ixekizumab Minor
- Ixekizumab + Phenytoin Minor
- Ixekizumab + Pneumococcal vaccine 13-valent Minor
- Ixekizumab + Quinidine Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Ixekizumab used for?
Ixekizumab is a medicine in the class miscellaneous. It is used for Ankylosing spondylitis, Psoriasis, Psoriatic arthritis, Spondyloarthritis.
What side effects have been reported with Ixekizumab?
Tinea infections, Serious infections, Upper respiratory tract infections, Injection site reacation, Thrombocytopenia, Nausea.
Can Ixekizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Human IgG is known to cross the placental barrier; therefore, the drug may be transmitted from the mother to the developing fetus Breastfeeding: Unknown. There are no available data on presence of this drug in human milk, effects on breastfed infant, or on milk production; the drug was detected in the milk of lactating cynomolgus monkeys; when a drug is present in animal milk, it is likely that the drug will be present in human milk
What does Ixekizumab interact with?
MediHelp lists 13 known interactions for Ixekizumab. Major: 2 · Moderate: 2 · Minor: 9. The most serious include Measles mumps and rubella vaccine, Upadacitinib, Ifosfamide.
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