Interazioni tra farmaci
Ixekizumab + Phenytoin
Gravità: Minore
Ixekizumab and Phenytoin: minor interaction.
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Sintesi
Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
Cosa significa questa interazione in parole semplici
Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Perché avviene
Normalisation of cytokine-suppressed CYP450 enzyme expression after IL-17A blockade may alter phenytoin metabolism.
Cosa fare
Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
Cosa chiedere al farmacista
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Doravirine + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
Altre interazioni di Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Maggiore
- Ixekizumab + Upadacitinib Maggiore
- Ifosfamide + Ixekizumab Moderata
- Ixekizumab + Lomustine Moderata
- Carbamazepine + Ixekizumab Minore
- Cyclosporin + Ixekizumab Minore
Domande frequenti
Can I take Ixekizumab with Phenytoin?
MediHelp rates the interaction as minor. Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
How serious is the interaction between Ixekizumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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