Riferimento farmaci
Lipegfilgrastim
Lipegfilgrastim is a medicine in the class miscellaneous. It is used for febrile neutropenia.
- Classe del farmaco: Miscellaneous
- Indicato per: febrile neutropenia
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- L03AA14
- Dosaggi comuni
- 6 mg
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Lipegfilgrastim is a PEGylated conjugate of filgrastim (recombinant methionyl human G-CSF) that binds the G-CSF receptor. It stimulates proliferation and differentiation of haematopoietic progenitor cells and release of neutrophils into the blood.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Reduction in duration of neutropenia and febrile neutropenia with cytotoxic chemotherapy: 6 mg (0.6 ml), subcutaneous, once for each chemotherapy cycle, given approximately 24 hours after cytotoxic chemotherapy
Gravidanza e allattamento
- Gravidanza
- Unknown Very limited human data (fewer than 300 pregnancies); animal studies showed reproductive toxicity. UK label: as a precaution, preferably avoid in pregnancy. Filgrastim has more pregnancy data and may be preferred.
- Allattamento
- Unknown Not known if it passes into milk. No LactMed record; related G-CSFs (filgrastim) pass poorly into milk and are not absorbed by the infant, but this long-acting form has no data. UK label: stop breastfeeding during treatment (risk cannot be excluded).
Effetti indesiderati segnalati
- Musculoskeletal pain
- Nausea
- Thrombocytopenia
- Hypokalaemia
- Headache
- Haemoptysis
Controindicazioni
- Hypersensitivity to the active substance or to any excipient.
Chi deve prestare attenzione
- Cross-reactivity: patients hypersensitive to G-CSF or derivatives should not start lipegfilgrastim.
- Not to be used to increase chemotherapy dose beyond established regimens; not investigated with high dose chemotherapy.
- Thrombocytopenia and leukocytosis may occur; monitor platelet count, haematocrit and WBC regularly.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Altri farmaci della stessa classe
Domande frequenti
What is Lipegfilgrastim used for?
Lipegfilgrastim is a medicine in the class miscellaneous. It is used for Febrile neutropenia, Neutropenia.
What side effects have been reported with Lipegfilgrastim?
Musculoskeletal pain, Nausea, Thrombocytopenia, Hypokalaemia, Headache, Haemoptysis.
Can Lipegfilgrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Very limited human data (fewer than 300 pregnancies); animal studies showed reproductive toxicity. UK label: as a precaution, preferably avoid in pregnancy. Filgrastim has more pregnancy data and may be preferred. Breastfeeding: Unknown. Not known if it passes into milk. No LactMed record; related G-CSFs (filgrastim) pass poorly into milk and are not absorbed by the infant, but this long-acting form has no data. UK label: stop breastfeeding during treatment (risk cannot be excluded).
What does Lipegfilgrastim interact with?
MediHelp does not list a checked interaction for Lipegfilgrastim yet. Always tell your pharmacist about every medicine you take.
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