Riferimento farmaci
Lomitapide
Lomitapide is a medicine in the class cardiovascular. It is used for hypercholesterolemia.
- Classe del farmaco: Cardiovascular
- Indicato per: hypercholesterolemia
Ultimo aggiornamento Fonti: US FDA label, EMA SmPC
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In breve
- Classe del farmaco
- Cardiovascular
- Codice ATC
- C10AX12
- Forme farmaceutiche comuni
- capsula
- Interazioni note
- 146 (Controindicata: 16 · Maggiore: 28 · Moderata: 68 · Minore: 34)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Binds and inhibits microsomal triglyceride transfer protein (MTP), preventing assembly of apo B-containing lipoproteins in enterocytes and hepatocytes. This inhibits chylomicron and VLDL synthesis and reduces plasma LDL-C.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
HoFH (18 years and older): start 5 mg orally once daily; titrate per Table 1 (weeks 0 to 2 at 5 mg, then 10 mg, 20 mg, 40 mg); maximum 60 mg daily from week 15, based on LDL-C target, safety and tolerability
Come si assume di solito
Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.
Gravidanza e allattamento
- Gravidanza
- Unsafe Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected.
- Allattamento
- Unsafe No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.
Effetti indesiderati segnalati
- Diarrhea
- Nausea
- Dyspepsia
- Abdominal pain
- Vomiting
- Chest pain
Avvertenze in evidenza
- Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis. Measure ALT, AST, alkaline phosphatase and bilirubin before starting, then ALT and AST regularly. Adjust dose if ALT or AST ≥3 times ULN and discontinue for clinically significant liver toxicity. Available only through the JUXTAPID REMS Program. Prescribe only for HoFH.
Controindicazioni
- Pregnancy
- Concomitant use with moderate or strong CYP3A4 inhibitors
- Moderate or severe hepatic impairment (Child-Pugh B or C) and active liver disease, including unexplained persistent transaminase elevations
Chi deve prestare attenzione
- Hepatotoxicity: transaminase elevations and hepatic steatosis; monitor liver tests before each dose increase or monthly in the first year, then at least every 3 months
- Embryo-fetal toxicity: may cause fetal harm; negative pregnancy test before starting and effective contraception during treatment and for two weeks after
- Reduced absorption of fat-soluble vitamins and fatty acids; daily vitamin E and essential fatty acid supplements needed
Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (146)
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
- Erythromycin + Lomitapide Contraindicated
- Fluconazole + Lomitapide Contraindicated
- Imatinib + Lomitapide Contraindicated
- Itraconazole + Lomitapide Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Lomitapide used for?
Lomitapide is a medicine in the class cardiovascular. It is used for Hypercholesterolemia.
What side effects have been reported with Lomitapide?
Diarrhea, Nausea, Dyspepsia, Abdominal pain, Vomiting, Chest pain. Serious warning: Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis.
Can Lomitapide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected. Breastfeeding: Unsafe. No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.
What does Lomitapide interact with?
MediHelp lists 146 known interactions for Lomitapide. Contraindicated: 16 · Major: 28 · Moderate: 68 · Minor: 34. The most serious include Aprepitant, Clarithromycin, Crizotinib.
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