Interazioni tra farmaci
Fluconazole + Lomitapide
Gravità: Controindicata
Fluconazole and Lomitapide: contraindicated interaction.
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Sintesi
Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
Cosa significa questa interazione in parole semplici
Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.
Perché avviene
Fluconazole inhibits CYP3A4, reducing the metabolism of lomitapide.
Cosa fare
Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Lomitapide
- Aprepitant + Lomitapide Controindicata
- Clarithromycin + Lomitapide Controindicata
- Crizotinib + Lomitapide Controindicata
- Diltiazem + Lomitapide Controindicata
- Efavirenz + Lomitapide Controindicata
- Ensitrelvir + Lomitapide Controindicata
Domande frequenti
Can I take Fluconazole with Lomitapide?
MediHelp rates the interaction as contraindicated. Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
How serious is the interaction between Fluconazole and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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