Riferimento farmaci
Methohexital
Methohexital is a medicine in the class central nervous system. It is used for general anesthesia.
- Classe del farmaco: Central Nervous System
- Indicato per: general anesthesia
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Central Nervous System
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 500 mg
- Interazioni note
- 118 (Maggiore: 27 · Moderata: 83 · Minore: 8)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Methohexital is a sulfur-free barbiturate anesthetic. After intravenous administration it is rapidly taken up by the brain (within 30 seconds) and rapidly induces sleep. With single doses, the rate of redistribution determines the duration of effect. It provides little analgesia.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Induction of anesthesia: 1% solution IV at about 1 mL/5 seconds; usual dose 1 to 1.5 mg/kg (range 50 to 120 mg or more, averages about 70 mg); provides anesthesia for 5 to 7 minutes
Gravidanza e allattamento
- Gravidanza
- Unknown No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose.
- Allattamento
- Safe Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
Effetti indesiderati segnalati
- Hypotension
- Tachycardia
- Respiratory depression including apnea
- Laryngospasm
- Hiccups
- Skeletal muscle twitching
Avvertenze in evidenza
- Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function. Resuscitative drugs, age- and size-appropriate airway equipment and trained personnel must be immediately available. Deeply sedated patients need a designated individual other than the proceduralist to monitor continuously.
Controindicazioni
- Patients in whom general anesthesia is contraindicated
- Latent or manifest porphyria
- Known hypersensitivity to barbiturates
Chi deve prestare attenzione
- Laryngospasm, apnea/hypoventilation and cardiorespiratory arrest may occur; maintain airway and ventilation
- Seizures may be elicited in patients with a history of convulsive activity, especially partial seizure disorders
- Unintended intra-arterial injection may cause thrombosis, necrosis and gangrene; use 1% concentration and confirm venous placement
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (118)
- Alprazolam + Methohexital Major
- Amobarbital + Methohexital Major
- Buprenorphine + Methohexital Major
- Chlordiazepoxide + Methohexital Major
- Chlordiazepoxide-clidinium + Methohexital Major
- Clemastine + Methohexital Major
- Clorazepate + Methohexital Major
- Clozapine + Methohexital Major
- Codeine + Methohexital Major
- Esketamine + Methohexital Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Methohexital used for?
Methohexital is a medicine in the class central nervous system. It is used for General anesthesia, General anesthesia adjunct.
What side effects have been reported with Methohexital?
Hypotension, Tachycardia, Respiratory depression including apnea, Laryngospasm, Hiccups, Skeletal muscle twitching. Serious warning: Use only in hospital or ambulatory care settings with continuous monitoring of respiratory and cardiac function.
Can Methohexital be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human studies; no developmental effects in rats and rabbits. FDA warns that lengthy or repeated general anaesthesia in the 3rd trimester may affect the developing brain (animal data). Use for needed anaesthesia or ECT at the usual dose. Breastfeeding: Safe. Amounts in milk are very small. US label: use with caution. LactMed: no waiting period is needed after a single dose; breastfeed as soon as the mother is alert enough. When several anaesthetic drugs are used, follow the most restrictive one.
What does Methohexital interact with?
MediHelp lists 118 known interactions for Methohexital. Major: 27 · Moderate: 83 · Minor: 8. The most serious include Alprazolam, Amobarbital, Buprenorphine.
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