Interazioni tra farmaci
Codeine + Methohexital
Gravità: Maggiore
Codeine and Methohexital: major interaction.
Ultimo aggiornamento
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Sintesi
Methohexital is a barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. With codeine, sedation, hypotension and respiratory depression are enhanced.
Cosa significa questa interazione in parole semplici
Codeine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Codeine belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Perché avviene
Additive CNS depression from GABA-A potentiation by the barbiturate and opioid receptor agonism.
Cosa fare
Use only in a monitored setting with equipment for airway support. Reduce the methohexital or opioid dose and monitor respiration and blood pressure.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Codeine
- Alvimopan + Codeine Controindicata
- Codeine + Isocarboxazid Controindicata
- Codeine + Olanzapine / samidorphan Controindicata
- Codeine + Phenelzine Controindicata
- Codeine + Tranylcypromine Controindicata
- Alfentanil + Codeine Maggiore
Altre interazioni di Methohexital
- Alprazolam + Methohexital Maggiore
- Amobarbital + Methohexital Maggiore
- Buprenorphine + Methohexital Maggiore
- Chlordiazepoxide-clidinium + Methohexital Maggiore
- Chlordiazepoxide + Methohexital Maggiore
- Clemastine + Methohexital Maggiore
Domande frequenti
Can I take Codeine with Methohexital?
MediHelp rates the interaction as major. Codeine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic that causes dose-dependent CNS and respiratory depression. With codeine, sedation, hypotension and respiratory depression are enhanced.
How serious is the interaction between Codeine and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in a monitored setting with equipment for airway support. Reduce the methohexital or opioid dose and monitor respiration and blood pressure.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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