Riferimento farmaci
Orlistat
Orlistat is a medicine in the class miscellaneous. It is used for obesity.
- Classe del farmaco: Miscellaneous
- Indicato per: obesity
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- A08AB01
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 120 mg, 60 mg
- Interazioni note
- 70 (Maggiore: 3 · Moderata: 44 · Minore: 23)
- Nomi commerciali
- 25
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Inhibits gastric and pancreatic lipases, prevents triglyceride hydrolysis resulting in decreased absorption of dietary fats
Dose abituale nell'adulto (sintesi del foglio illustrativo)
(Xenical): 120 mg PO q8hr with each fat-containing meal (during or up to 1 hr after the meal), doses >120 mg TID show no additional benefit
Gravidanza e allattamento
- Gravidanza
- Unknown Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution.
- Allattamento
- Safe Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
Effetti indesiderati segnalati
- Flatulence
- Oily spotting
- Fatty/oily stool
- Increased defecation
Chi deve prestare attenzione
- Daily fat intake (30% of calories), carbohydrate, and protein should be evenly distributed over 3 main meals
- Postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure with some cases resulting in liver transplant or death
- Some patients may develop increased levels of urinary oxalate following treatment; cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure reported
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (70)
- Cyclosporin + Orlistat Major
- Cyclosporine + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
- Clobazam + Orlistat Moderate
- Clonazepam + Orlistat Moderate
- Clorazepate + Orlistat Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Domande frequenti
What is Orlistat used for?
Orlistat is a medicine in the class miscellaneous. It is used for Obesity.
What side effects have been reported with Orlistat?
Flatulence, Oily spotting, Fatty/oily stool, Increased defecation.
Can Orlistat be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution. Breastfeeding: Safe. Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
What does Orlistat interact with?
MediHelp lists 70 known interactions for Orlistat. Major: 3 · Moderate: 44 · Minor: 23. The most serious include Cyclosporin, Cyclosporine, Triheptanoin.
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