Interazioni tra farmaci
Cyclosporine + Orlistat
Gravità: Maggiore
Cyclosporine and Orlistat: major interaction.
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Sintesi
Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
Cosa significa questa interazione in parole semplici
Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Orlistat reduces dietary fat absorption and may impair absorption of the highly lipophilic cyclosporine from the gut.
Cosa fare
Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Orlistat
- Cyclosporin + Orlistat Maggiore
- Orlistat + Triheptanoin Maggiore
- Amiodarone + Orlistat Moderata
- Beta carotene + Orlistat Moderata
- Carbamazepine + Orlistat Moderata
- Cholecalciferol + Orlistat Moderata
Domande frequenti
Can I take Cyclosporine with Orlistat?
MediHelp rates the interaction as major. Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
How serious is the interaction between Cyclosporine and Orlistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporin, Triheptanoin, Amiodarone. The full list is on the Orlistat page.
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