Interazioni tra farmaci
Amiodarone + Orlistat
Gravità: Moderata
Amiodarone and Orlistat: moderate interaction.
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Sintesi
Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
Cosa significa questa interazione in parole semplici
Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Orlistat belongs to Miscellaneous.
Perché avviene
Reduced intestinal absorption of lipophilic amiodarone due to lipase inhibition and reduced fat availability.
Cosa fare
Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amiodarone
- Amiodarone + Amisulpride Controindicata
- Amiodarone + Arsenic trioxide Controindicata
- Amiodarone + Dofetilide Controindicata
- Amiodarone + Dronedarone Controindicata
- Amiodarone + Droperidol Controindicata
- Amiodarone + Eliglustat Controindicata
Altre interazioni di Orlistat
- Cyclosporine + Orlistat Maggiore
- Cyclosporin + Orlistat Maggiore
- Orlistat + Triheptanoin Maggiore
- Beta carotene + Orlistat Moderata
- Carbamazepine + Orlistat Moderata
- Cholecalciferol + Orlistat Moderata
Domande frequenti
Can I take Amiodarone with Orlistat?
MediHelp rates the interaction as moderate. Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
How serious is the interaction between Amiodarone and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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