Riferimento farmaci
Piperacillin-tazobactam
Piperacillin-tazobactam is a medicine in the class anti bacterial. It is used for female pelvic infections.
- Classe del farmaco: Anti Bacterial
- Indicato per: female pelvic infections
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Anti Bacterial
- Forme farmaceutiche comuni
- iniezione, infusione
- Dosaggi comuni
- 4.5 g, 2.25 g, 2 g
- Interazioni note
- 54 (Maggiore: 1 · Moderata: 32 · Minore: 21)
- Nomi commerciali
- 30
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Antipseudomonal penicillin plus beta-lactamase inhibitor; inhibits biosynthesis of cell wall mucopeptide synthesis by binding to 1 or more of the penicillin-binding proteins and is effective during active-multiplication stage
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Intra-abdominal Infections: 3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 days
Come si assume di solito
Penicillin antibiotics are taken by mouth or given by injection at regular intervals for a set number of days; the course should be completed even when symptoms improve early.
Gravidanza e allattamento
- Gravidanza
- Safe Both drugs cross the placenta; there are insufficient data to show a risk, and penicillins have long use in pregnancy without evidence of fetal harm. No malformations in rats or mice. Safe to use when indicated.
- Allattamento
- Safe Piperacillin passes into milk in low amounts, not expected to harm the infant; tazobactam is unstudied. LactMed: occasionally diarrhoea or thrush. Acceptable; breastfeeding can continue.
Effetti indesiderati segnalati
- Headache
- Diarrhea
- Nausea
- Insomnia
- Constipation
- Fever
Controindicazioni
- Allergy to penicillins, cephalosporins, imipenem, beta-lactamase inhibitors
Chi deve prestare attenzione
- Prolonged use may result in fungal or bacterial superinfection
- Leukopenia/neutropenia associated with prolonged therapy; periodic assessment of hematopoietic function should be performed,
- Increased frequency of fever and rash reported in patients with cystic fibrosis receiving piperacillin
Anyone who has had an allergic reaction to a penicillin or another beta-lactam antibiotic must tell the prescriber before taking one. Severe or persistent diarrhoea during or after a course needs medical advice.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (54)
- Piperacillin-tazobactam + Vancomycin Major
- Amikacin + Piperacillin-tazobactam Moderate
- Antithrombin alfa + Piperacillin-tazobactam Moderate
- Antithrombin iii + Piperacillin-tazobactam Moderate
- Argatroban + Piperacillin-tazobactam Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Balstilimab + Piperacillin-tazobactam Moderate
- Bcg vaccine live + Piperacillin-tazobactam Moderate
- Bivalirudin + Piperacillin-tazobactam Moderate
- Camrelizumab + Piperacillin-tazobactam Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Piperacillin-tazobactam used for?
Piperacillin-tazobactam is a medicine in the class anti bacterial. It is used for Female pelvic infections, Intra-abdominal infections, Pneumonia, Sepsis, Skin infections.
What side effects have been reported with Piperacillin-tazobactam?
Headache, Diarrhea, Nausea, Insomnia, Constipation, Fever.
Can Piperacillin-tazobactam be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Both drugs cross the placenta; there are insufficient data to show a risk, and penicillins have long use in pregnancy without evidence of fetal harm. No malformations in rats or mice. Safe to use when indicated. Breastfeeding: Safe. Piperacillin passes into milk in low amounts, not expected to harm the infant; tazobactam is unstudied. LactMed: occasionally diarrhoea or thrush. Acceptable; breastfeeding can continue.
What does Piperacillin-tazobactam interact with?
MediHelp lists 54 known interactions for Piperacillin-tazobactam. Major: 1 · Moderate: 32 · Minor: 21. The most serious include Vancomycin, Amikacin, Antithrombin alfa.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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