Riferimento farmaci
Ampicillin-sulbactam
Ampicillin-sulbactam is a medicine in the class anti bacterial. It is used for cellulitis.
- Classe del farmaco: Anti Bacterial
- Indicato per: cellulitis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Anti Bacterial
- Forme farmaceutiche comuni
- iniezione, compressa, sospensione orale, polvere
- Dosaggi comuni
- 375 mg, 750 mg, 1500 mg
- Interazioni note
- 45 (Maggiore: 1 · Moderata: 15 · Minore: 29)
- Nomi commerciali
- 44
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Drug combination of beta-lactamase inhibitor with ampicillin; interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms; alternative to amoxicillin when unable to take medication orally; covers skin, enteric flora, and anaerobes; not ideal for nosocomial pathogens.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Gynecologic Infections: 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day
Come si assume di solito
Penicillin antibiotics are taken by mouth or given by injection at regular intervals for a set number of days; the course should be completed even when symptoms improve early.
Gravidanza e allattamento
- Gravidanza
- Safe Ampicillin and sulbactam cross the placenta; studies show no harm, and penicillins are widely used in pregnancy. Considered a safe choice when needed.
- Allattamento
- Safe Both components pass into milk in small amounts. Acceptable; watch the infant for diarrhoea, thrush or rash.
Effetti indesiderati segnalati
- Diarrhea
- IM injection site pain
- IV injection site pain
- Thrombophlebitis
Controindicazioni
- Hypersensitivity to drug or components
- Patients with previous history of cholestatic jaundice/hepatic dysfunction associated with ampicillin sulbactam
Chi deve prestare attenzione
- Patients with previous history of cholestatic jaundice/hepatic dysfunction associated with ampicillin sulbactam
- A generalized dull red maculopapular rash may occur in 5-10% of children 3-14 days after initiating therapy
Anyone who has had an allergic reaction to a penicillin or another beta-lactam antibiotic must tell the prescriber before taking one. Severe or persistent diarrhoea during or after a course needs medical advice.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (45)
- Ampicillin-sulbactam + Methotrexate Major
- Allopurinol + Ampicillin-sulbactam Moderate
- Ampicillin-sulbactam + Bcg vaccine live Moderate
- Ampicillin-sulbactam + Chloramphenicol Moderate
- Ampicillin-sulbactam + Cholera vaccine Moderate
- Ampicillin-sulbactam + Demeclocycline Moderate
- Ampicillin-sulbactam + Doxycycline Moderate
- Ampicillin-sulbactam + Eravacycline Moderate
- Ampicillin-sulbactam + Microbiota Moderate
- Ampicillin-sulbactam + Minocycline Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Ampicillin-sulbactam used for?
Ampicillin-sulbactam is a medicine in the class anti bacterial. It is used for Cellulitis, Gynecologic infections, Intra-abdominal infections, Skin infections, Urinary tract infections.
What side effects have been reported with Ampicillin-sulbactam?
Diarrhea, IM injection site pain, IV injection site pain, Thrombophlebitis.
Can Ampicillin-sulbactam be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Ampicillin and sulbactam cross the placenta; studies show no harm, and penicillins are widely used in pregnancy. Considered a safe choice when needed. Breastfeeding: Safe. Both components pass into milk in small amounts. Acceptable; watch the infant for diarrhoea, thrush or rash.
What does Ampicillin-sulbactam interact with?
MediHelp lists 45 known interactions for Ampicillin-sulbactam. Major: 1 · Moderate: 15 · Minor: 29. The most serious include Methotrexate, Allopurinol, Bcg vaccine live.
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