Riferimento farmaci
Secnidazole
Secnidazole is a medicine in the class anti parasitic. It is used for bacterial vaginosis.
- Classe del farmaco: Anti Parasitic
- Indicato per: bacterial vaginosis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Anti Parasitic
- Forme farmaceutiche comuni
- compressa, bustina
- Dosaggi comuni
- 500 mg, 1 g, 2 g/4.8 g
- Interazioni note
- 1 (Moderata: 1)
- Nomi commerciali
- 13
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Secnidazole is a nitroimidazole derivative; 5-nitroimidazoles enters the bacterial cell as an inactive prodrug where the nitro group is reduced by bacterial enzymes to radical anions. It is believed that these radical anions interfere with bacterial DNA synthesis of susceptible isolates
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Bacterial Vaginosis: 1 packet (2 grams) of granules or tablet PO once as a single dose, without regard to timing of meals
Gravidanza e allattamento
- Gravidanza
- Unknown Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy.
- Allattamento
- Unknown No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
Effetti indesiderati segnalati
- Headache
- Vomiting
- Diarrhea
- Nausea
- Vulvovaginal candidiasis
- Dysgeusia
Controindicazioni
- Hypersensitivity to secnidazole, excipients of the formulation, or other nitroimidazole derivatives
- Patients with Cockayne syndrome
Chi deve prestare attenzione
- Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes reported after initiation of metronidazole in patients with Cockayne syndrome
- Carcinogenicity has been seen in mice and rats treated long term with nitroimidazole derivatives, which are structurally related to secnidazole; avoid long-term use
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (1)
- Ethanol + Secnidazole Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Secnidazole used for?
Secnidazole is a medicine in the class anti parasitic. It is used for Bacterial vaginosis, Trichomoniasis.
What side effects have been reported with Secnidazole?
Headache, Vomiting, Diarrhea, Nausea, Vulvovaginal candidiasis, Dysgeusia.
Can Secnidazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy. Breastfeeding: Unknown. No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
What does Secnidazole interact with?
MediHelp lists 1 known interactions for Secnidazole. Moderate: 1. The most serious include Ethanol.
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