Riferimento farmaci
Pentamidine
Pentamidine is a medicine in the class anti parasitic. It is used for pneumonia.
- Classe del farmaco: Anti Parasitic
- Indicato per: pneumonia
Ultimo aggiornamento Fonti: US FDA label
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
In breve
- Classe del farmaco
- Anti Parasitic
- Forme farmaceutiche comuni
- iniezione, inalatore
- Dosaggi comuni
- 300 mg/3 ml, 300 mg/6 ml
- Interazioni note
- 156 (Controindicata: 9 · Maggiore: 113 · Moderata: 33 · Minore: 1)
- Nomi commerciali
- 2
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Aromatic diamidine; mode of action not fully understood. In vitro it interferes with protozoal nuclear metabolism by inhibiting DNA, RNA, phospholipid and protein synthesis.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Pneumocystis carinii pneumonia: 4 mg/kg once a day, IM or IV, for 14 to 21 days; therapy longer than 21 days may be associated with increased toxicity
Gravidanza e allattamento
- Gravidanza
- Unknown Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first.
- Allattamento
- Unknown Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.
Effetti indesiderati segnalati
- Elevated serum creatinine
- Impaired renal function
- Sterile abscess, necrosis, pain or induration at IM site
- Leukopenia
- Elevated liver function tests
- Azotemia
Controindicazioni
- History of hypersensitivity to pentamidine isethionate.
Chi deve prestare attenzione
- Fatalities from severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported with IM and IV use; limit use to patients with demonstrated Pneumocystis carinii.
- Sudden severe hypotension can occur after a single dose; patients should lie down with close blood pressure monitoring and resuscitation equipment available.
- Extravasation may cause ulceration, tissue necrosis or sloughing; discontinue the infusion and restart in another vein.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (156)
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Pentamidine + Ziprasidone Contraindicated
- Adefovir + Pentamidine Major
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per aprire la monografia completa di Pentamidine: dosi, gravidanza e allattamento, effetti indesiderati, avvertenze e tutte le interazioni.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altri farmaci della stessa classe
Domande frequenti
What is Pentamidine used for?
Pentamidine is a medicine in the class anti parasitic. It is used for Pneumonia.
What side effects have been reported with Pentamidine?
Elevated serum creatinine, Impaired renal function, Sterile abscess, necrosis, pain or induration at IM site, Leukopenia, Elevated liver function tests, Azotemia.
Can Pentamidine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.
What does Pentamidine interact with?
MediHelp lists 156 known interactions for Pentamidine. Contraindicated: 9 · Major: 113 · Moderate: 33 · Minor: 1. The most serious include Clomipramine, Desipramine, Dronedarone.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
