Riferimento farmaci
Tretinoin
Tretinoin is a medicine in the class dermatology. It is used for acne.
- Classe del farmaco: Dermatology
- Indicato per: acne
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Dermatology
- Forme farmaceutiche comuni
- crema, gel, capsula, soluzione, lozione
- Dosaggi comuni
- 0.05%, 0.025%, 10 mg
- Interazioni note
- 65 (Maggiore: 7 · Moderata: 20 · Minore: 38)
- Nomi commerciali
- 28
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Retinoid, induces differentiation and decreased proliferation of APL cells; produces an initial maturation of promyelocytes, followed by a repopulation of the bone marrow and peripheral blood by normal polyclonal hematopoietic cells in patients achieving complete remission
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Acute Promyelocytic Leukemia: 45 mg/m²/day PO divided q12hr, Discontinue 30 days after complete remission or 90 days after start of treatment (whichever comes first)
Gravidanza e allattamento
- Gravidanza
- Unsafe Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant.
- Allattamento
- Unsafe Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
Effetti indesiderati segnalati
- Headache
- Pruritus
- Bone pain
- Erythema
- Fever
- Excessive dryness
Chi deve prestare attenzione
- Systemic: Leukocytosis may occur
- Systemic: Do not coadminister with other retinoids or in combination with vitamin A because symptoms of hypervitaminosis A
- Systemic: There is risk of thrombosis (both venous and arterial) which may involve any organ system, during first month of treatment
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Interazioni principali (65)
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
- Tranexamic acid + Tretinoin Major
- Aminolevulinic acid + Tretinoin Moderate
- Chlorpromazine + Tretinoin Moderate
- Ciprofloxacin + Tretinoin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Tretinoin used for?
Tretinoin is a medicine in the class dermatology. It is used for Acne, Leukemia, Melasma, Wrinkles.
What side effects have been reported with Tretinoin?
Headache, Pruritus, Bone pain, Erythema, Fever, Excessive dryness.
Can Tretinoin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant. Breastfeeding: Unsafe. Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
What does Tretinoin interact with?
MediHelp lists 65 known interactions for Tretinoin. Major: 7 · Moderate: 20 · Minor: 38. The most serious include Doxycycline, Minocycline, Omadacycline.
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