Riferimento farmaci
Valbenazine
Valbenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.
- Classe del farmaco: Central Nervous System
- Indicato per: tardive dyskinesia
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Central Nervous System
- Forme farmaceutiche comuni
- capsula
- Interazioni note
- 135 (Controindicata: 2 · Maggiore: 24 · Moderata: 105 · Minore: 4)
- Nomi commerciali
- 2
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Mechanism in tardive dyskinesia and Huntington's chorea is unclear, but thought to be mediated through reversible inhibition of vesicular monoamine transporter 2 (VMAT2), which regulates monoamine uptake from the cytoplasm into synaptic vesicles.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Tardive dyskinesia: initial 40 mg orally once daily; after one week increase to the recommended 80 mg once daily; 40 mg or 60 mg once daily may be considered depending on response and tolerability.
Gravidanza e allattamento
- Gravidanza
- Unsafe May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk.
- Allattamento
- Unsafe No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.
Effetti indesiderati segnalati
- Somnolence (somnolence, fatigue, sedation)
- Anticholinergic effects
- Balance disorders/fall
- Headache
- Akathisia
- Vomiting
Avvertenze in evidenza
- VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease. Balance these risks against the clinical need for chorea treatment, monitor closely for emergence or worsening of depression, suicidality or unusual behavior changes, inform patients, caregivers and families to report concerning behaviors promptly, and use particular caution in patients with a history of depression or prior suicide attempts or ideation.
Controindicazioni
- History of hypersensitivity to valbenazine or any components of the product.
Chi deve prestare attenzione
- Hypersensitivity reactions including angioedema (involving larynx, glottis, lips, eyelids) can occur and may be fatal; discontinue if they occur.
- Somnolence and sedation: avoid driving or operating hazardous machinery until effects are known.
- QT prolongation: may be clinically significant with strong CYP2D6/CYP3A4 inhibitors or in CYP2D6 poor metabolizers; avoid in congenital long QT syndrome or arrhythmias associated with prolonged QT.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (135)
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
- Cisapride + Valbenazine Major
- Clarithromycin + Valbenazine Major
- Dronedarone + Valbenazine Major
- Enzalutamide + Valbenazine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Domande frequenti
What is Valbenazine used for?
Valbenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.
What side effects have been reported with Valbenazine?
Somnolence (somnolence, fatigue, sedation), Anticholinergic effects, Balance disorders/fall, Headache, Akathisia, Vomiting. Serious warning: VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease.
Can Valbenazine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk. Breastfeeding: Unsafe. No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.
What does Valbenazine interact with?
MediHelp lists 135 known interactions for Valbenazine. Contraindicated: 2 · Major: 24 · Moderate: 105 · Minor: 4. The most serious include Deutetrabenazine, Tranylcypromine, Amiodarone.
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