Interazioni tra farmaci
Tranylcypromine + Valbenazine
Gravità: Controindicata
Tranylcypromine and Valbenazine: contraindicated interaction.
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Sintesi
Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
Cosa significa questa interazione in parole semplici
Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tranylcypromine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Perché avviene
Opposing effects on monoamine disposition: VMAT2 inhibition versus MAO inhibition preventing monoamine breakdown.
Cosa fare
Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tranylcypromine
- 5-HTP + Tranylcypromine Controindicata
- Amitriptyline + Tranylcypromine Controindicata
- Amoxapine + Tranylcypromine Controindicata
- Atomoxetine + Tranylcypromine Controindicata
- Benzphetamine + Tranylcypromine Controindicata
- Brimonidine + Tranylcypromine Controindicata
Altre interazioni di Valbenazine
- Deutetrabenazine + Valbenazine Controindicata
- Amiodarone + Valbenazine Maggiore
- Amisulpride + Valbenazine Maggiore
- Apalutamide + Valbenazine Maggiore
- Carbamazepine + Valbenazine Maggiore
- Cisapride + Valbenazine Maggiore
Domande frequenti
Can I take Tranylcypromine with Valbenazine?
MediHelp rates the interaction as contraindicated. Tranylcypromine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Valbenazine is a VMAT2 inhibitor that depletes monoamines, and MAOIs raise synaptic monoamine levels. The combination may reduce valbenazine efficacy and may increase the risk of serotonin toxicity. Labeling contraindicates concomitant use with MAOIs.
How serious is the interaction between Tranylcypromine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative therapy. Observe the washout period recommended in the labeling when changing between agents.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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