Interazioni tra farmaci
Deutetrabenazine + Valbenazine
Gravità: Controindicata
Deutetrabenazine and Valbenazine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
Cosa significa questa interazione in parole semplici
Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Perché avviene
Duplicate VMAT2 inhibition causes additive pharmacodynamic effects and excessive monoamine depletion.
Cosa fare
Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Controindicata
- Deutetrabenazine + Linezolid Controindicata
- Deutetrabenazine + Phenelzine Controindicata
- Deutetrabenazine + Rasagiline Controindicata
- Deutetrabenazine + Safinamide Controindicata
- Deutetrabenazine + Selegiline Controindicata
Altre interazioni di Valbenazine
- Tranylcypromine + Valbenazine Controindicata
- Amiodarone + Valbenazine Maggiore
- Amisulpride + Valbenazine Maggiore
- Apalutamide + Valbenazine Maggiore
- Carbamazepine + Valbenazine Maggiore
- Cisapride + Valbenazine Maggiore
Domande frequenti
Can I take Deutetrabenazine with Valbenazine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
How serious is the interaction between Deutetrabenazine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
What other medicines interact with Deutetrabenazine?
MediHelp also lists interactions of Deutetrabenazine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Deutetrabenazine page.
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