Interazioni tra farmaci
Abacavir + Methadone
Gravità: Minore
Abacavir and Methadone: minor interaction.
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Sintesi
Abacavir may modestly increase methadone clearance, which could occasionally lead to reduced opioid effect or withdrawal symptoms. In studies the changes in methadone exposure were small and dose adjustment was generally not needed.
Cosa significa questa interazione in parole semplici
Abacavir and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Abacavir belongs to Anti Virals; Methadone belongs to Musculoskeletal.
Perché avviene
Possible modest increase in methadone clearance; the exact mechanism is not established.
Cosa fare
Monitor for withdrawal symptoms or reduced effect after starting abacavir and increase the methadone dose only if clinically needed.
Cosa chiedere al farmacista
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Altre interazioni di Methadone
- Alvimopan + Methadone Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Methadone Controindicata
- Droperidol + Methadone Controindicata
- Ibutilide + Methadone Controindicata
- Isocarboxazid + Methadone Controindicata
- Lefamulin + Methadone Controindicata
Altre interazioni di Abacavir
- Abacavir + Ribavirin Moderata
- Abacavir + Efavirenz Minore
- Abacavir + Emtricitabine Minore
- Abacavir + Ganciclovir Minore
- Abacavir + Nevirapine Minore
- Abacavir + Valganciclovir Minore
Domande frequenti
Can I take Abacavir with Methadone?
MediHelp rates the interaction as minor. Abacavir and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Abacavir may modestly increase methadone clearance, which could occasionally lead to reduced opioid effect or withdrawal symptoms. In studies the changes in methadone exposure were small and dose adjustment was generally not needed.
How serious is the interaction between Abacavir and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or reduced effect after starting abacavir and increase the methadone dose only if clinically needed.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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