Interazioni tra farmaci
Droperidol + Methadone
Gravità: Controindicata
Droperidol and Methadone: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and methadone also prolongs QTc. The combination also increases sedation and respiratory depression.
Cosa significa questa interazione in parole semplici
Droperidol and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive QTc prolongation through hERG potassium channel blockade, with additive central nervous system depression.
Cosa fare
Avoid the combination and choose a non-QT-prolonging antiemetic or sedative. If it cannot be avoided, use continuous ECG monitoring and correct electrolytes first.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Methadone
- Alvimopan + Methadone Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Methadone Controindicata
- Ibutilide + Methadone Controindicata
- Isocarboxazid + Methadone Controindicata
- Lefamulin + Methadone Controindicata
- Levoketoconazole + Methadone Controindicata
Domande frequenti
Can I take Droperidol with Methadone?
MediHelp rates the interaction as contraindicated. Droperidol and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and methadone also prolongs QTc. The combination also increases sedation and respiratory depression.
How serious is the interaction between Droperidol and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antiemetic or sedative. If it cannot be avoided, use continuous ECG monitoring and correct electrolytes first.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Ibutilide. The full list is on the Methadone page.
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