Interazioni tra farmaci
Ibutilide + Methadone
Gravità: Controindicata
Ibutilide and Methadone: contraindicated interaction.
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Sintesi
Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
Cosa significa questa interazione in parole semplici
Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
Perché avviene
Additive pharmacodynamic QT prolongation via potassium channel (hERG) blockade.
Cosa fare
Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Methadone
- Alvimopan + Methadone Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Methadone Controindicata
- Droperidol + Methadone Controindicata
- Isocarboxazid + Methadone Controindicata
- Lefamulin + Methadone Controindicata
- Levoketoconazole + Methadone Controindicata
Altre interazioni di Ibutilide
- Amiodarone + Ibutilide Controindicata
- Amisulpride + Ibutilide Controindicata
- Chlorpromazine + Ibutilide Controindicata
- Clarithromycin + Ibutilide Controindicata
- Desipramine + Ibutilide Controindicata
- Dolasetron + Ibutilide Controindicata
Domande frequenti
Can I take Ibutilide with Methadone?
MediHelp rates the interaction as contraindicated. Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
How serious is the interaction between Ibutilide and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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