Interazioni tra farmaci
Adefovir + Streptomycin
Gravità: Maggiore
Adefovir and Streptomycin: major interaction.
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Sintesi
Adefovir can cause dose-related proximal tubular nephrotoxicity, and streptomycin is also nephrotoxic. Concurrent use increases the risk of kidney injury and may raise aminoglycoside exposure and ototoxicity.
Cosa significa questa interazione in parole semplici
Adefovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Adefovir belongs to Anti Virals; Streptomycin belongs to Anti Bacterial.
Perché avviene
Additive nephrotoxicity affecting the proximal tubule, with reduced clearance of renally eliminated drugs.
Cosa fare
Avoid concurrent use when possible. If necessary, monitor serum creatinine and phosphate regularly, adjust adefovir dosing interval to renal function, and monitor streptomycin levels and hearing.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Streptomycin
- Abobotulinumtoxina + Streptomycin Maggiore
- Amikacin + Streptomycin Maggiore
- Amphotericin b deoxycholate + Streptomycin Maggiore
- Amphotericin b + Streptomycin Maggiore
- Atracurium + Streptomycin Maggiore
- Bacitracin + Streptomycin Maggiore
Altre interazioni di Adefovir
- Adefovir + Elvitegravir / cobicistat / emtricitabine / tenofovir df Controindicata
- Adefovir + Amikacin Maggiore
- Adefovir + Amphotericin b Maggiore
- Adefovir + Amphotericin b deoxycholate Maggiore
- Adefovir + Bacitracin Maggiore
- Adefovir + Capreomycin Maggiore
Domande frequenti
Can I take Adefovir with Streptomycin?
MediHelp rates the interaction as major. Adefovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adefovir can cause dose-related proximal tubular nephrotoxicity, and streptomycin is also nephrotoxic. Concurrent use increases the risk of kidney injury and may raise aminoglycoside exposure and ototoxicity.
How serious is the interaction between Adefovir and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If necessary, monitor serum creatinine and phosphate regularly, adjust adefovir dosing interval to renal function, and monitor streptomycin levels and hearing.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Amikacin, Amphotericin b deoxycholate. The full list is on the Streptomycin page.
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