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Interazioni tra farmaci

Amphotericin b + Streptomycin

Gravità: Maggiore

Amphotericin b and Streptomycin: major interaction.

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Sintesi

Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Combined use increases the risk of kidney injury, which can further raise aminoglycoside levels and toxicity.

Cosa significa questa interazione in parole semplici

Amphotericin b and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amphotericin b belongs to Anti Fungals; Streptomycin belongs to Anti Bacterial.

Livello di evidenza: Moderate

Perché avviene

Additive nephrotoxicity with reduced aminoglycoside clearance, increasing ototoxicity risk.

Cosa fare

Avoid concurrent use if possible; otherwise monitor renal function and streptomycin levels and assess hearing and balance. Ensure adequate hydration.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amphotericin b with Streptomycin?

MediHelp rates the interaction as major. Amphotericin b and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Combined use increases the risk of kidney injury, which can further raise aminoglycoside levels and toxicity.

How serious is the interaction between Amphotericin b and Streptomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise monitor renal function and streptomycin levels and assess hearing and balance. Ensure adequate hydration.

What other medicines interact with Amphotericin b?

MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.

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