Interazioni tra farmaci
Amphotericin b deoxycholate + Streptomycin
Gravità: Maggiore
Amphotericin b deoxycholate and Streptomycin: major interaction.
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Sintesi
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
Cosa significa questa interazione in parole semplici
Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive nephrotoxicity, with impaired renal function increasing aminoglycoside accumulation and ototoxicity.
Cosa fare
Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Streptomycin
- Abobotulinumtoxina + Streptomycin Maggiore
- Adefovir + Streptomycin Maggiore
- Amikacin + Streptomycin Maggiore
- Amphotericin b + Streptomycin Maggiore
- Atracurium + Streptomycin Maggiore
- Bacitracin + Streptomycin Maggiore
Domande frequenti
Can I take Amphotericin b deoxycholate with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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