Interazioni tra farmaci
Alendronate + Calcium carbonate
Gravità: Moderata
Alendronate and Calcium carbonate: moderate interaction.
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Sintesi
Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
Cosa significa questa interazione in parole semplici
Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alendronate belongs to Musculoskeletal; Calcium carbonate belongs to Gastrointestinal Tract.
Perché avviene
Divalent calcium cations form insoluble complexes with alendronate in the gastrointestinal tract, reducing absorption.
Cosa fare
Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Calcium carbonate
- Acalabrutinib + Calcium carbonate Moderata
- Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate Moderata
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium carbonate Moderata
- Atazanavir + Calcium carbonate Moderata
- Atenolol + Calcium carbonate Moderata
- Azilsartan-chlorthalidone + Calcium carbonate Moderata
Altre interazioni di Alendronate
- Aceclofenac + Alendronate Moderata
- Acemetacin + Alendronate Moderata
- Acetylsalicylic acid + Alendronate Moderata
- Alendronate + Aluminum hydroxide Moderata
- Alendronate + Aspirin Moderata
- Alendronate + Aspirin / citric acid / sodium bicarbonate Moderata
Domande frequenti
Can I take Alendronate with Calcium carbonate?
MediHelp rates the interaction as moderate. Alendronate and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts bind alendronate in the gut and markedly reduce its already low absorption. This can lead to loss of bisphosphonate efficacy.
How serious is the interaction between Alendronate and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take alendronate fasting with plain water at least 30 minutes before calcium or any other food, drink or medication. Give calcium supplements later in the day.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Calcium carbonate page.
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