Interazioni tra farmaci
Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate
Gravità: Moderata
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate: moderate interaction.
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Sintesi
Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
Cosa significa questa interazione in parole semplici
Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
Perché avviene
Thiazide-reduced renal calcium excretion plus calcium load leading to hypercalcemia.
Cosa fare
Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Controindicata
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Maggiore
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Maggiore
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Maggiore
Altre interazioni di Calcium carbonate
Domande frequenti
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium carbonate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and with calcium carbonate this can cause hypercalcemia and milk-alkali syndrome, especially with high doses or renal impairment. High-dose calcium may also reduce calcium channel blocker effects, although this is rarely clinically significant at usual intakes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, particularly with high calcium doses or long-term use. Reduce calcium supplementation if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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