Interazioni tra farmaci
Amlodipine-olmesartan-hydrochlorothiazide + Calcium carbonate
Gravità: Moderata
Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate: moderate interaction.
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Sintesi
Calcium salts can reduce the effect of calcium channel blockers in cases of high-dose or intravenous calcium, but oral calcium carbonate has little effect on amlodipine. Thiazides reduce urinary calcium excretion, so with large calcium carbonate doses there is a risk of hypercalcemia and milk-alkali syndrome.
Cosa significa questa interazione in parole semplici
Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
Perché avviene
Thiazide-reduced renal calcium excretion combined with calcium load, with minimal pharmacodynamic antagonism of amlodipine at oral doses.
Cosa fare
Monitor serum calcium in patients taking regular or high-dose calcium supplements or antacids. Reduce calcium dose if hypercalcemia occurs.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Controindicata
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Maggiore
Altre interazioni di Calcium carbonate
Domande frequenti
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium carbonate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium salts can reduce the effect of calcium channel blockers in cases of high-dose or intravenous calcium, but oral calcium carbonate has little effect on amlodipine. Thiazides reduce urinary calcium excretion, so with large calcium carbonate doses there is a risk of hypercalcemia and milk-alkali syndrome.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients taking regular or high-dose calcium supplements or antacids. Reduce calcium dose if hypercalcemia occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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