Interazioni tra farmaci
Allogeneic cultured keratinocytes and fibroblasts + Silver sulfadiazine
Gravità: Moderata
Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Silver sulfadiazine applied to a wound leaves silver ions that are toxic to living cells. This can reduce the viability of the cultured keratinocytes and fibroblasts in the cell-based skin product and impair graft take.
Cosa significa questa interazione in parole semplici
Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Local cytotoxicity of silver ions toward cultured human keratinocytes and fibroblasts.
Cosa fare
Do not apply silver sulfadiazine or silver dressings to the site before or at the time of application of the cellular product. Rinse the wound bed thoroughly if silver was previously used.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Silver sulfadiazine
- Collagenase + Silver sulfadiazine Moderata
- Papain + Silver sulfadiazine Moderata
- Silver sulfadiazine + Trypsin Moderata
Domande frequenti
Can I take Allogeneic cultured keratinocytes and fibroblasts with Silver sulfadiazine?
MediHelp rates the interaction as moderate. Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silver sulfadiazine applied to a wound leaves silver ions that are toxic to living cells. This can reduce the viability of the cultured keratinocytes and fibroblasts in the cell-based skin product and impair graft take.
How serious is the interaction between Allogeneic cultured keratinocytes and fibroblasts and Silver sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not apply silver sulfadiazine or silver dressings to the site before or at the time of application of the cellular product. Rinse the wound bed thoroughly if silver was previously used.
What other medicines interact with Silver sulfadiazine?
MediHelp also lists interactions of Silver sulfadiazine with, for example, Collagenase, Papain, Trypsin. The full list is on the Silver sulfadiazine page.
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