Interazioni tra farmaci
Alvimopan + Fentanyl
Gravità: Controindicata
Alvimopan and Fentanyl: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
Cosa significa questa interazione in parole semplici
Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
Cosa fare
Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fentanyl
- Fentanyl + Isocarboxazid Controindicata
- Fentanyl + Olanzapine / samidorphan Controindicata
- Fentanyl + Phenelzine Controindicata
- Fentanyl + Tranylcypromine Controindicata
- Alfentanil + Fentanyl Maggiore
- Alprazolam + Fentanyl Maggiore
Domande frequenti
Can I take Alvimopan with Fentanyl?
MediHelp rates the interaction as contraindicated. Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
How serious is the interaction between Alvimopan and Fentanyl?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Fentanyl page.
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